Ro 67-7476

CAS No. 298690-60-5

Ro 67-7476( —— )

Catalog No. M17468 CAS No. 298690-60-5

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 77 In Stock
10MG 120 In Stock
25MG 244 In Stock
50MG 441 In Stock
100MG 644 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ro 67-7476
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
  • Description
    Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
  • In Vitro
    In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5.?Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM). The EC50?value of? full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC50?value of 17.7 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    mGluR1
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    298690-60-5
  • Formula Weight
    319.39
  • Molecular Formula
    C17H18FNO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 40 mg/mL; 125.24 mM
  • SMILES
    N1([C@@H](CCC1)c1ccc(cc1)F)S(=O)(=O)c1ccc(cc1)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hemstapat K et al. Mol Pharmacol. 2006 Aug, 70(2), 616-26
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